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The central melanocortin system and the regulation of energy balance

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14 On the one hand, GSH reductase converts GSSG to GSH using NADPH as an important cofactor, then GSH acts as a cosubstrate for GSH peroxidase (GPX) that reduces hydrogen peroxide (H 2 O 2 ) and other peroxides to H 2 O or alcohol to deactivate ROS